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It is now known that the MHC makeup on the floor of those cells is altered and the NK cells become activated by way of recognition of “missing self”. Normal body cells usually are not acknowledged and attacked by NK cells as a result of they specific intact self MHC antigens.
An example is HIV, which mutates quickly, so the proteins on its viral envelope which are important for entry into its host target cell are constantly changing. These frequent changes in antigens may explain the failures of vaccines directed at this virus. The parasite Trypanosoma brucei makes use of an identical strategy, constantly switching one kind of surface protein for one more, allowing it to remain one step forward of the antibody response.
In one small examine of people who had inoperable pancreatic, colorectal, or liver cancers, … Read More